procedures

Bone Marrow Trephine Biopsy

Sources

Bone Marrow Trephine Biopsy — 2025-11-20

Procedure Details

  • Date: 2025-11-20 (sample generated 13:09, accepted 14:49)
  • Facility: KIMS Health, Trivandrum
  • Referring Physician: Ashwin V Nair
  • Biopsy No: B25-15264
  • Bill No: L085234025
  • Billed at: 2025-11-20 12:50
  • Authorized at: 2025-11-26 10:48 (6 days turnaround)

Clinical Indication

Complaints of pancytopenia.

Specimen

Two brownish linear cores of tissue, each measuring 0.3 cm (1 bit AE).

Histopathology Report

Microscopy

Bony core showing 6–7 fragmented marrow spaces showing extensive crushing. Focal area shows 60% cellularity with atypical mononuclear cell infiltrate admixed with normal hematopoietic precursors.

Special Stains

  • Reticulin: Grade 1–2
  • PAS: No additional findings
  • Perls (iron stain): Inconclusive

Diagnosis

  • Fragmented marrow tissue with crushing and immature cell infiltrate admixed with hematopoietic elements
  • Recommendation: Please follow bone marrow aspiration / flow cytometry report

Reported By

Dr. Neetu S Dathan, MBBS, Fellowship in Oncopathology, MD Pathology

Interpretation

The biopsy shows a hypercellular marrow (60% cellularity, which is higher than expected for an 81-year-old) with an atypical mononuclear cell infiltrate. The reticulin grade 1–2 suggests early fibrosis. The extensive fragmentation and crushing limit full assessment. Flow cytometry is recommended to characterize the atypical cells — this could represent a lymphoproliferative disorder, myelodysplastic syndrome, or other infiltrative process.

Follow-up

Updated automatically during ingest.

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