Renerve
Sources
Renerve
Formulation
Renerve is an Indian brand neurological supplement. The standard Renerve tablet formulation contains:
- Methylcobalamin (B12): 1500 mcg
- Alpha Lipoic Acid: 100 mg
- Pyridoxine HCl (B6): 3 mg
- Folic Acid: 1.5 mg
[!note] Exact formulation should be confirmed from the prescription or pharmacy label. Multiple Renerve variants (Renerve Plus, Renerve G) exist with differing compositions.
Clinical Context
Documented by: Two 2026-04-29 clinic notes:
- raw/clinic-notes/2026-04-29_note.md (primary)
- raw/clinic-notes/20260429_124418_note.md (confirmation — identical content: "taking renerve once daily")
Documentation: Patient reported taking "renerve once daily" — prescriber and exact indication not stated in either note. Both notes corroborate the same information.
Likely indications in this patient's context:
1. Chemotherapy-induced neuropathy prophylaxis or treatment — Azacitidine + Venetoclax can cause peripheral neuropathy; B12/B6/ALA supplementation is commonly prescribed as neuroprotection in Indian oncology practice.
2. B12 deficiency prevention — Elderly patients (age 81) are at elevated risk for B12 deficiency, which compounds macrocytosis already present from AML/chemotherapy.
3. Alpha lipoic acid — Antioxidant; used adjunctively in diabetic neuropathy (relevant given Diabetes Mellitus).
Dose History
| Date | Dose | Frequency | Change | Source |
|---|---|---|---|---|
| 2026-04-29 | 1 tablet | Once daily | Started (or documented for first time) | 2026-04-29 clinic note |
Relevance to Active Conditions
- Aml — Neuroprotection during Aza-Ven chemotherapy
- Diabetes Mellitus — Alpha lipoic acid component used in diabetic neuropathy; B12 deficiency more common in diabetic patients (especially if on metformin, though no metformin is documented)
- Anemia — Macrocytosis (MCV elevated throughout) could be worsened by B12 deficiency; methylcobalamin supplementation is appropriate
Drug Interactions
- No known significant interactions with azacitidine, venetoclax, acyclovir, or posaconazole.
- Alpha lipoic acid may have mild hypoglycemic effect — monitor blood glucose in diabetic patient.
Monitoring
- Serum B12 level — Baseline not documented. Consider checking to confirm adequacy of supplementation.
- Peripheral neuropathy assessment — No formal neurological exam documented. Presence/absence of chemotherapy-induced peripheral neuropathy (CIPN) not recorded.