Serum Free Light Chains (Kappa & Lambda)
Sources
Serum Free Light Chains (Kappa & Lambda)
Longitudinal Data
| Date | Kappa (mg/L) | Lambda (mg/L) | K/L Ratio | Flag | Source |
|---|---|---|---|---|---|
| 2025-11-19 | 36.81 | 26.73 | 1.377 | Kappa H, Lambda H, Ratio N | CCR_4182YK007572_734983f.pdf |
- Lab: DDRC Agilus Diagnostics (Accession 4182YK007572)
- Drawn: 2025-11-19
- Reported: 2025-11-20
- Reported by: Dr. Devi C B, MBBS, MD, Consultant Biochemist
Interpretation
Both kappa (36.81, ref 3.3–19.4) and lambda (26.73, ref 5.71–26.3) free light chains are elevated, but the kappa/lambda ratio is normal (1.377, ref 0.26–1.65). This pattern indicates a polyclonal elevation of free light chains, which is consistent with:
- Inflammatory states
- Renal impairment (though creatinine was normal)
- Hematologic malignancy with reactive immune activation
Importantly, the normal ratio rules out a monoclonal plasma cell process (multiple myeloma, primary amyloidosis, light chain deposition disease). Combined with the negative M-spike on Spep, monoclonal gammopathy is effectively excluded.
This result was initially reported as PENDING on the preliminary lab report but was finalized on the same accession's final report.
See also: Spep, Aml, Positive Ana