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Serum Protein Electrophoresis (SPEP)
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Serum Protein Electrophoresis (SPEP)
Longitudinal Data
| Date | Total Protein | M-Spike | Pattern | A/G Ratio | Source |
|---|---|---|---|---|---|
| 2025-11-19 | 7.42 g/dL | Not seen | Inflammatory | 1.20 | CCR_4182YK007572_734983f.pdf |
Fraction Detail (2025-11-19)
| Fraction | % | Ref % | Conc (g/dL) | Ref Conc (g/dL) | Flag |
|---|---|---|---|---|---|
| Albumin | 54.6 | 55.8–66.1 | 4.05 | 4.02–4.76 | L (%) |
| Alpha-1 | 5.4 | 2.9–4.9 | 0.40 | 0.21–0.35 | H |
| Alpha-2 | 11.7 | 7.1–11.8 | 0.87 | 0.51–0.85 | N (borderline H) |
| Beta-1 | 5.1 | 4.7–7.2 | 0.38 | 0.34–0.52 | N |
| Beta-2 | 6.3 | 3.2–6.5 | 0.47 | 0.23–0.47 | N |
| Gamma | 16.9 | 11.1–18.8 | 1.25 | 0.80–1.35 | N |
- Lab: DDRC Agilus Diagnostics (Accession 4182YK007572)
- Drawn: 2025-11-19
- Reported: 2025-11-20
- Method: Capillary electrophoresis
- Reported by: Dr. Devi C B, MBBS, MD, Consultant Biochemist
- Comment: Inflammatory pattern. Recommendation: Repeat electrophoresis in 3–6 months.
Interpretation
The SPEP shows an inflammatory pattern characterized by:
- Mildly increased Alpha-1 and Alpha-2 fractions (acute phase reactants)
- Normal gamma fraction (no monoclonal spike)
- No M-spike detected — rules out monoclonal gammopathy/myeloma
This pattern is consistent with the inflammatory state associated with Aml and is concordant with the elevated Esr (130 mm/hr) and Crp (13.8 mg/L) obtained on the same date.
[!note] Follow-up recommended
Report recommends repeat SPEP in 3–6 months (by May 2026). This would be relevant to monitor for any emerging monoclonal protein given the AML diagnosis.
See also: Free Light Chains, Aml, Positive Ana