Positive ANA
Positive ANA
Clinical Summary
ANA (Antinuclear Antibody) was found positive at 2.2 (reference <1.0) on 2025-11-19 at DDRC Agilus Diagnostics. This was part of an autoimmune workup in the context of Pancytopenia.
Supporting Serology
| Test | Value | Reference | Interpretation |
|---|---|---|---|
| ANA | 2.2 | <1.0 negative | Positive |
| Anti-dsDNA | 29.1 IU/ml | <100 negative | Negative |
| Anti-CCP | <7.00 U/mL | ≤17.00 | Negative |
| CRP | 13.80 mg/L | <5 | Elevated |
| ESR | 130 mm/hr | 0–35 | Markedly elevated |
| Complement C3 | 140.0 mg/dL | 90–180 | Normal |
| Complement C4 | 39.3 mg/dL | 10–40 | Normal |
| Ceruloplasmin | 29.10 mg/dL | 16–45 (F) | Normal — Wilson's ruled out |
| Copper, serum | 124.5 ug/dL | 80–155 (F) | Normal — Copper Serum |
Interpretation
- Positive ANA with negative anti-dsDNA and anti-CCP makes SLE and RA less likely
- Normal complement levels further argue against active lupus
- Elevated inflammatory markers (ESR, CRP) suggest active systemic inflammation
- ANA positivity in an elderly patient can be non-specific — prevalence of low-titer ANA increases with age
- Clinical correlation needed in context of pancytopenia
Additional Workup (Nov 2025) — Results Now Available
The following tests were initially reported as PENDING but final results are now available (from the final version of accession 4182YK007572):
- Serum protein electrophoresis (SPEP) — Inflammatory pattern, no M-spike. Rules out myeloma/paraproteinemia.
- Serum free light chains (Kappa & Lambda) — Kappa 36.81 (H), Lambda 26.73 (H), ratio 1.377 (normal). Polyclonal elevation — rules out monoclonal gammopathy.
- Copper, serum — 124.5 ug/dL (normal). Completes Wilson's disease rule-out alongside normal ceruloplasmin.
Peripheral Smear Context
The Peripheral Smear 2025 11 19 obtained simultaneously showed pancytopenia with eosinophil predominance (13%) and atypical lymphocytes (3%), adding eosinophilic disorders and reactive conditions to the differential at the time.
Follow-up
- ANA pattern and titer not specified — may need further characterization (method was ELISA, not IFA)
- Consider ENA panel (anti-Smith, anti-RNP, anti-SSA, anti-SSB) if autoimmune etiology pursued
- Monitor serially in context of overall clinical course
- The subsequent Aml diagnosis largely explains the pancytopenia, making the ANA positivity likely incidental
Updated automatically during ingest.